ea0065p198 | Metabolism and Obesity | SFEBES2019
Ali Usama
, Suba Kinga
, Bitsi Stavroula
, Alonso Aldara Martin
, Patel Yateen
, Leclerc Isabelle
, Rutter Guy A
, Rothery Stephen
, Salem Victoria
, Tomas Alejandra
Background: Islet transplantation is an established treatment for type 1 diabetes mellitus. However, many recipients do not achieve independence from exogenous insulin since up to 5070% of islets are lost post-transplant. An important factor determining transplant success is graft vascularisation. The epidermal growth factor receptor (EGFR) is a key pro-survival and proliferation factor. Here, we investigate for the first time if EGFR overexpression in pancreatic islets ...